Which statement correctly pairs primary hypergonadism with its typical cause?

Which statement correctly pairs primary hypergonadism with its typical cause?

• A. Primary hypergonadism — Testicular tumor
• B. Primary hypergonadism — Precocious puberty
• C. Primary hypergonadism — Kallmann syndrome
• D. Primary hypergonadism — Klinefelter syndrome

Answer: (A)

Primary hypergonadism means the gonads themselves are overactive, producing excess sex hormones independent of pituitary control. The clearest example of this is a gonadal tumor that secretes testosterone directly, causing high testosterone levels and signs of puberty earlier than normal. That’s why a testicular tumor is the best pairing. The other conditions describe situations where gonadal function is reduced or where the problem lies upstream in the hormonal axis: Kallmann syndrome is a form of hypogonadotropic hypogonadism (low GnRH signaling), Klinefelter syndrome involves primary testicular failure with low testosterone, and precocious puberty can arise from central activation or peripheral sources but does not typify primary hypergonadism.

Primary hypergonadism means the gonads themselves are overactive, producing excess sex hormones independent of pituitary control. The clearest example of this is a gonadal tumor that secretes testosterone directly, causing high testosterone levels and signs of puberty earlier than normal. That’s why a testicular tumor is the best pairing. The other conditions describe situations where gonadal function is reduced or where the problem lies upstream in the hormonal axis: Kallmann syndrome is a form of hypogonadotropic hypogonadism (low GnRH signaling), Klinefelter syndrome involves primary testicular failure with low testosterone, and precocious puberty can arise from central activation or peripheral sources but does not typify primary hypergonadism.