Which apolipoprotein is predominantly distributed in HDL and has a structural role?

Which apolipoprotein is predominantly distributed in HDL and has a structural role?

• A. ApoA2
• B. ApoA1
• C. ApoA4
• D. ApoB100

Answer: (A)

HDL particles carry several apolipoproteins, with different roles in HDL structure and metabolism. The apolipoprotein that is predominantly distributed on HDL and provides a structural stabilizing role is ApoA-II. It commonly exists as disulfide-linked dimers and helps maintain HDL particle integrity and size. In contrast, ApoA-I is the major HDL apolipoprotein and drives functional activities such as promoting cholesterol efflux and activating LCAT. ApoB-100 is a constituent of apoB-containing lipoproteins like VLDL and LDL, not HDL, and ApoA-IV is present to some extent on HDL but is not the dominant structural component.

HDL particles carry several apolipoproteins, with different roles in HDL structure and metabolism. The apolipoprotein that is predominantly distributed on HDL and provides a structural stabilizing role is ApoA-II. It commonly exists as disulfide-linked dimers and helps maintain HDL particle integrity and size. In contrast, ApoA-I is the major HDL apolipoprotein and drives functional activities such as promoting cholesterol efflux and activating LCAT. ApoB-100 is a constituent of apoB-containing lipoproteins like VLDL and LDL, not HDL, and ApoA-IV is present to some extent on HDL but is not the dominant structural component.