In brain tissue, which marker is more abundant: CKBB or Aldolase C?

In brain tissue, which marker is more abundant: CKBB or Aldolase C?

• A. CKBB
• B. Aldolase C
• C. CK1
• D. AST

Answer: (A)

Brain tissue relies heavily on rapid ATP regeneration through the phosphocreatine system. The brain-type creatine kinase isoenzyme, CK-BB, is the dominant CK form in brain and is specialized for buffering high-energy phosphate needs during neuronal activity. Aldolase C, while present in brain and part of glycolysis, is not as abundant as CK-BB in brain tissue. Therefore, CK-BB is the more plentiful marker in brain tissue.

Brain tissue relies heavily on rapid ATP regeneration through the phosphocreatine system. The brain-type creatine kinase isoenzyme, CK-BB, is the dominant CK form in brain and is specialized for buffering high-energy phosphate needs during neuronal activity. Aldolase C, while present in brain and part of glycolysis, is not as abundant as CK-BB in brain tissue. Therefore, CK-BB is the more plentiful marker in brain tissue.