For transaminase elevations, acute hepatitis and liver necrosis reach what multiple of ULN?

For transaminase elevations, acute hepatitis and liver necrosis reach what multiple of ULN?

• A. 2x ULN
• B. 5x ULN
• C. 10x ULN
• D. 20x ULN

Answer: (C)

When hepatocytes are damaged, transaminases leak out into the blood, so their serum levels rise with the extent of injury. In acute hepatitis and liver necrosis, many hepatocytes are affected, causing a substantial spill of these enzymes. This pattern commonly yields transaminase elevations about ten times the upper limit of normal. While more extreme cases like ischemic or massive necrosis can push levels higher, around 10x ULN is the typical magnitude associated with acute hepatocellular injury.

When hepatocytes are damaged, transaminases leak out into the blood, so their serum levels rise with the extent of injury. In acute hepatitis and liver necrosis, many hepatocytes are affected, causing a substantial spill of these enzymes. This pattern commonly yields transaminase elevations about ten times the upper limit of normal. While more extreme cases like ischemic or massive necrosis can push levels higher, around 10x ULN is the typical magnitude associated with acute hepatocellular injury.